دانلود کتاب DNA Methyltransferases - Role and Function 2nd Edition
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توضیحات کتاب:
This 2nd edition of the book on DNA methyltransferases has been comprehensively updated to reflect many novel research findings regarding the structure, function, and technology of these enzymes that have emerged over the past 6 years.
Like the previous edition, this 2nd edition explains the biochemical properties of DNA methyltransferases, describing their structures, mechanisms and biological roles in bacteria, humans and plants. It also discusses the biological processes of reading DNA methylation and the mechanisms of DNA demethylation. This volume highlights the newest findings on DNA methyltransferase inhibitors and their use in cancer therapy as well as the latest epigenome editing systems based on these enzymes.
Overall, this 2nd edition comprehensively summarizes the current state of research in the field of DNA methylation and DNA methyltransferase and is essential reading for early career and advanced researchers in this exciting field.
Contents: فهرست فصول
1. Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges
2. DNA Methylation in Prokaryotes
3. Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases
4. Enzymology of Mammalian DNA Methyltransferases
5. Genetic Studies on Mammalian DNA Methyltransferases
6. Structure and Mechanism of Plant DNA Methyltransferases
7. DNA Methylation in Honey Bees and the Unresolved Questions in Insect Methylomics
8. N6-methyladenine: A Rare and Dynamic DNA Mark
9. Pathways of DNA Demethylation
10. Structure and Function of TET Enzymes
11. Proteins That Read DNA Methylation
12. Recent Advances on DNA Base Flipping: A General Mechanism for Writing, Reading, and Erasing DNA Modifications
13. The Role of DNA Methylation and DNA Methyltransferases in Cancer
14. DNA Methyltransferases and DNA Damage
15. Role of DNMTs in the Brain
16. Current and Emerging Technologies for the Analysis of the Genome-Wide and Locus-Specific DNA Methylation Patterns
17. Inhibitors of DNA Methylation
18. Gene-Targeted DNA Methylation: Towards Long-Lasting Reprogramming of Gene Expression?
19. DNA Labeling Using DNA Methyltransferases
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