Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition equips you with an unsurpassed understanding of modern toxicology, including the key principles, concepts, mechanisms, chemical-specific toxicity, and modes of thought that are the foundation of the discipline. This trusted classic not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date, revealing, and in-depth look at the systemic responses of toxic substance available anywhere.
Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition is logically divided into seven sections:
Many new contributors capture the progress made in toxicology over the past few years:This edition is markedly updated from the previous edition, with more than one-third of the chapters authored by scientists who have not made previous contributions to the book.
Sharing their expertise, they deliver dynamic new coverage of the importance of apoptosis, autophagy, cytokines, growth factors, oncogenes, cell cycling, receptors, gene regulation, protective mechanisms, repair mechanisms, transcription factors, signaling pathways, transgenic mice, knock-out mice, humanized mice, polymorphisms, microarray technology, second-generation sequencing, genomics, proteomics, epigenetics, exposome, microbiota, read across, adverse outcome pathways, high-content screening, computational toxicology, innovative test methods, and organ-on-a-chip in understanding the mechanisms of toxicity and the regulation of chemicals.A true “essential”If you are in need of an up-to-date, all-in-one overview of the biomedical and environmental aspects of toxicology – written by experts, and presented in full color, your search ends here.
Contents: فهرست فصول
CoverTitle PageCopyright PageHistory and DedicationContentsContributorsPrefacePreface to the First EditionUnit I General Principles of Toxicology1. The Evolving Journey of Toxicology: A Historical Glimpse2. Principles of Toxicology3. Mechanisms of Toxicity4. Risk AssessmentUnit II Disposition of Toxicants5 Absorption, Distribution, and Excretion of Toxicants6 Biotransformation of Xenobiotics7 ToxicokineticsUnit III Non-Organ-Directed Toxicity8 Chemical Carcinogenesis9 Genetic Toxicology10 Developmental ToxicologyUnit IV Target Organ Toxicity11 Toxic Responses of the Blood12 Toxic Responses of the Immune System13 Toxic Responses of the Liver14 Toxic Responses of the Kidney15 Toxic Responses of the Respiratory System16 Toxic Responses of the Nervous System17 Toxic Responses of the Cornea, Retina, and Central Visual System18 Toxic Responses of the Heart and Vascular System19 Toxic Responses of the Skin20 Toxic Responses of the Endocrine System21 Toxic Responses of the Reproductive SystemUnit V Toxic Agents22 Toxic Effects of Pesticides23 Toxic Effects of Metals24 Toxic Effects of Solvents and Vapors25 Toxic Effects of Radiation and Radioactive Materials26 Toxic Effects of Plants and Animals27 Food Toxicology: Fundamental and Regulatory Aspects28 Toxic Effects of Calories29 Nanoparticle ToxicologyUnit VI Environmental Toxicology30 Ecotoxicology31 Air PollutionUnit VII Applications of Toxicology32 Analytical and Forensic Toxicology33 Clinical Toxicology34 Occupational Toxicology35 Regulatory ToxicologyIndex