The new and fully-revised volume of hematologic molecular biology for practicing and trainee hematologists
Molecular Hematology is a comprehensive resource for hematologists to increase their understanding of the molecular basis of various blood diseases, their pathogeneses, and current and emerging molecular research and therapies. The impact of molecular research on the field of hematology is significant—molecular techniques are continuing to play a central role in in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has increased our comprehension of the causes of hematological diseases and led to the development of new drug therapies and recombinant proteins.
Now in its fourth edition, Molecular Hematology has been thoroughly revised and updated to reflect current advances in molecular research. Chapters introduce and summarize specific disorders, such as hemophilia, anemia, and multiple myeloma, and illustrate the impact of molecular research on their diagnoses and treatments. Contributions written by respected clinicians and researchers offer accessible coverage of topics including lymphoma genetics, molecular coagulation and thrombophilia, platelet disorders, pharmacogenomics, and many others.
Molecular Hematology is an essential volume for both trainee and practicing hematologists and oncologists, molecular biologists, and research scientists working in the field of hematology.
Contents: فهرست فصول
Contributors ixPreface to the fourth edition xiiiFurther reading xvAcknowledgments xvi1 Beginnings: the molecular pathology of hemoglobin 1David Weatherall2 Stem cells 21David T. Scadden3 The genetics of acute myeloid leukemias 37Amy M. Trottier & Carolyn J. Owen4 Molecular diagnostics and risk assessment in myeloid malignancies 49Christian Scharenberg & Torsten Haferlach5 Molecular basis of acute lymphoblastic leukemia 59Bela Patel & Fiona Fernando6 Chronic myeloid leukemia 71Hagop Kantarjian, Jorge Cortes, Elias Jabbour & Susan O’Brien7 Myeloproliferative neoplasms 87Jyoti Nangalia, Anthony J. Bench, Anthony R. Green & Anna L. Godfrey8 Lymphoma genetics 101Jennifer L. Crombie, Anthony Letai & John G. Gribben9 The molecular biology of chronic lymphocytic leukemia 111John G. Gribben10 The molecular biology of multiple myeloma 121Wee Joo Chng & P. Leif Bergsagel11 The molecular basis of bone marrow failure syndromes and red cell enzymopathies 131Deena Iskander, Lucio Luzzatto & Anastasios Karadimitris12 Anemia of chronic disease 155Tomas Ganz13 The molecular basis of iron metabolism 161Nancy C. Andrews & Tomas Ganz14 Hemoglobinopathies due to structural mutations 173D. Mark Layton & Steven Okoli15 Molecular pathogenesis of malaria 193David J. Roberts, Arnab Pain & Chetan E. Chitnis16 Molecular coagulation and thrombophilia 207Bj?rn Dahlb?ck & Andreas Hillarp17 The molecular basis of hemophilia 221Daniel P. Hart & Paul L.F. Giangrande18 The molecular basis of von Willebrand disease 235Luciano Baronciani19 Platelet disorders 251Kenneth J. Clemetson20 The molecular basis of blood cell alloantigens 267Cristina Navarrete, Louise Tilley, Winnie Chong & Colin J. Brown21 Functions of blood group antigens 285Jonathan S. Stamler & Marilyn J. Telen22 Autoimmune hematological disorders 297Drew Provan & John W. Semple23 Molecular therapeutics in hematology: gene therapy 319William M. McKillop & Jeffrey A. Medin24 Pharmacogenomics 339Leo Kager & William E. Evans25 History and development of molecular biology 353Paul Moss26 Cancer stem cells 363Sara Ali & Dominique Bonnet27 Molecular basis of transplantation 373Francesco Dazzi & Antonio GalleuIndex 389