دانلود کتاب بیوشیمی هارپر 2018 Harper's Illustrated Biochemistry 31 ED
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توضیحات کتاب:
The Thirty-First Edition of Harper’s Illustrated Biochemistry continues to emphasize the link between biochemistry and the understanding of disease states, disease pathology, and the practice of medicine. Featuring a full-color presentation and numerous medically relevant examples, Harper’s presents a clear, succinct review of the fundamentals of biochemistry that every student must understand in order to succeed in medical school.
All 58 chapters help you understand the medical relevance of biochemistry:
•Full-color presentation includes more than 600 illustrations
•Case studies emphasize the clinical relevance of biochemistry
•NEW CHAPTER on Biochemistry of Transition Metals addresses the importance and overall pervasiveness of transition metals
•Review Questions follow each of the eleven sections
•Boxed Objectives define the goals of each chapter
•Tables encapsulate important information
•Every chapter includes a section on the biomedical importance of a given topic
NEW TO THIS EDITION:
•Emphasis throughout on the integral relationship between biochemistry and disease, diagnostic pathology, and medical practice
•Hundreds of references to disease states throughout
•New chapter addressing the biochemical roles of transition metals
•Many updated review questions
•Frequent tables summarizing key links to disease states
•New text on cryo-electron microscopy (cryo-EM)
•Cover picture of the protein structure of the Zika virus, solved by cryo-EM
Applauded by medical students and online reviewers for its currency and engaging style, Harper’s Illustrated Biochemistry is essential for USMLE® review and the single-best reference for learning the clinical relevance of any biochemistry topic.
Contents فهرست فصول :
SECTION I Structures & Functions of Proteins & Enzymes
۱ Biochemistry & Medicine
Victor W. Rodwell, PhD, & Robert K. Murray, MD, PhD
۲ Water & pH
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
۳ Amino Acids & Peptides
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
۴ Proteins: Determination of Primary Structure
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
۵ Proteins: Higher Orders of Structure
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
SECTION II Enzymes: Kinetics, Mechanism, Regulation, & Role of Transition Metals
۶ Proteins: Myoglobin & Hemoglobin
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
۷ Enzymes: Mechanism of Action
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
۸ Enzymes: Kinetics
Victor W. Rodwell, PhD
۹ Enzymes: Regulation of Activities
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
۱۰ The Biochemical Roles of Transition Metals
Peter J. Kennelly, PhD
SECTION III Bioenergetics
۱۱ Bioenergetics: The Role of ATP
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
۱۲ Biologic Oxidation
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
۱۳ The Respiratory Chain & Oxidative Phosphorylation
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
SECTION IV Metabolism of Carbohydrates
۱۴ Overview of Metabolism & the Provision of Metabolic Fuels
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
۱۵ Carbohydrates of Physiological Significance
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
۱۶ The Citric Acid Cycle: The Central Pathway of Carbohydrate, Lipid, & Amino Acid Metabolism
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
۱۷ Glycolysis & the Oxidation of Pyruvate
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
۱۸ Metabolism of Glycogen
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
۱۹ Gluconeogenesis & the Control of Blood Glucose
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
۲۰ The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
SECTION V Metabolism of Lipids
۲۱ Lipids of Physiologic Significance
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
۲۲ Oxidation of Fatty Acids: Ketogenesis
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
۲۳ Biosynthesis of Fatty Acids & Eicosanoids
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
۲۴ Metabolism of Acylglycerols & Sphingolipids
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
۲۵ Lipid Transport & Storage
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
۲۶ Cholesterol Synthesis, Transport, & Excretion
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
SECTION VI Metabolism of Proteins & Amino Acids
۲۷ Biosynthesis of the Nutritionally Nonessential Amino Acids
Victor W. Rodwell, PhD
۲۸ Catabolism of Proteins & of Amino Acid Nitrogen
Victor W. Rodwell, PhD
۲۹ Catabolism of the Carbon Skeletons of Amino Acids
Victor W. Rodwell, PhD
۳۰ Conversion of Amino Acids to Specialized Products
Victor W. Rodwell, PhD
۳۱ Porphyrins & Bile Pigments
Victor W. Rodwell, PhD & Robert K. Murray, MD, PhD
SECTION VII Structure, Function, & Replication of Informational Macromolecules
۳۲ Nucleotides
Victor W. Rodwell, PhD
۳۳ Metabolism of Purine & Pyrimidine Nucleotides
Victor W. Rodwell, PhD
۳۴ Nucleic Acid Structure & Function
P. Anthony Weil, PhD
۳۵ DNA Organization, Replication, & Repair
P. Anthony Weil, PhD
۳۶ RNA Synthesis, Processing, & Modification
P. Anthony Weil, PhD
۳۷ Protein Synthesis & the Genetic Code
P. Anthony Weil, PhD
۳۸ Regulation of Gene Expression
P. Anthony Weil, PhD
۳۹ Molecular Genetics, Recombinant DNA, & Genomic
Technology
P. Anthony Weil, PhD
SECTION VIII Biochemistry of Extracellular & Intracellular Communication
۴۰ Membranes: Structure & Function
P. Anthony Weil, PhD
۴۱ The Diversity of the Endocrine System
P. Anthony Weil, PhD
۴۲ Hormone Action & Signal Transduction
P. Anthony Weil, PhD
(SECTION IX Special Topics (A
۴۳ Nutrition, Digestion, & Absorption
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
۴۴ Micronutrients: Vitamins & Minerals
David A. Bender, PhD
۴۵ Free Radicals & Antioxidant Nutrients
David A. Bender, PhD
۴۶ Glycoproteins
David A. Bender, PhD & Robert K. Murray, MD, PhD
۴۷ Metabolism of Xenobiotics
David A. Bender, PhD & Robert K. Murray, MD, PhD
۴۸ Clinical Biochemistry
David A. Bender, PhD & Robert K. Murray, MD, PhD
(SECTION X Special Topics (B
۴۹ Intracellular Traffic & Sorting of Proteins
Kathleen M. Botham, PhD, DSc & Robert K. Murray, MD, PhD
۵۰ The Extracellular Matrix
Kathleen M. Botham, PhD, DSc & Robert K. Murray, MD, PhD
۵۱ Muscle & the Cytoskeleton
Peter J. Kennelly, PhD and Robert K. Murray, MD, PhD
۵۲ Plasma Proteins & Immunoglobulins
Peter J. Kennelly, PhD, Robert K. Murray, MD, PhD, Molly Jacob, MBBS, MD, PhD & Joe Varghese, MBBS, MD
۵۳ Red Blood Cells
Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD
۵۴ White Blood Cells
Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD
(SECTION XI Special Topics (C
۵۵ Hemostasis & Thrombosis
Peter L. Gross, MD, MSc, FRCP(C), P. Anthony Weil, PhD & Margaret L. Rand, PhD
۵۶ Cancer: An Overview
Molly Jacob, MD, PhD, Joe Varghese, PhD & P. Anthony Weil, PhD
۵۷ The Biochemistry of Aging
Peter J. Kennelly, PhD
۵۸ Biochemical Case Histories
David A. Bender, PhD
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